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Article

Molecular and clinical characterization of H3 K27M-mutant "non-midline" glioblastoma: A case report and literature review.

Neurocirugia (English Edition) - 1 Jan 2000

Onishi Shumpei, Ohba Shinji, Kuraoka Kazuya, Kurashige Takashi, Sugiyama Kazuhiko, Yamasaki Fumiyuki

Abstract excerpt

The WHO classification of tumors of the CNS in 2016 defined "diffuse midline glioma, H3 K27M-mutant" as a new tumor entity locating in the CNS midline. However, the H3 K27M-mutation in "non-midline" glioblastoma are rare and their characteristics have been rarely reported. A 16-year-old girl presented a hyper-intense lesion at her left temporal stem on T2WI, FLAIR and DWI. Biopsy was performed and molecular...

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PMID: 36333093
DOI: 10.1016/j.neucie.2021.06.008

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