Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Stabilization of nuclear oncoproteins by RNF4 and the ubiquitin system in cancer

18 Nov 2016

Abstract excerpt

RNF4, a SUMO-targeted ubiquitin ligase, stabilizes a selected group of oncoproteins. It potentiates oncoprotein activity and serves as a positive feedback agonist of Wnt and Notch pathways. RNF4 is essential for cancer cell survival and its levels are elevated in human cancers, correlating with poor outcome in a subset of cancer patients.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28197534
DOI: 10.1080/23723556.2016.1260671

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stabilization of nuclear oncoproteins by RNF4 and the ubiquitin system in cancerPMID 28197534Read ↗

RNF4-Dependent Oncogene Activation by Protein StabilizationSemantic proximity Read ↗

RNF4—A Paradigm for SUMOylation‐Mediated UbiquitinationSemantic proximity Read ↗

Smurfs in Protein Homeostasis, Signaling, and CancerSemantic proximity Read ↗

RNF4 promotes tumorigenesis, therapy resistance of cholangiocarcinoma and affects cell cycle by regulating the ubiquitination degradation of p27kip1 in the nucleusSemantic proximity Read ↗

RNF13: an emerging RING finger ubiquitin ligase important in cell proliferationSemantic proximity Read ↗

RNF5 Regulation of RBBP4 Defines Acute Myeloid Leukemia Growth and Susceptibility to Histone Deacetylase InhibitorsSemantic proximity Read ↗

Unraveling the Potential Role of NEDD4-like E3 Ligases in CancerSemantic proximity Read ↗

A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks.Semantic proximity Read ↗

A Functional Reference Map of RNF8 Interactome in CancersSemantic proximity Read ↗

Hepatocyte nuclear factor 4α and cancer-related cell signaling pathways: a promising insight into cancer treatmentSemantic proximity Read ↗

USP4 expression independently predicts favorable survival in lung adenocarcinomaSemantic proximity Read ↗

NEDD4 E3 ubiquitin ligases: Promising biomarkers and therapeutic targets for cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.