USP4 expression independently predicts favorable survival in lung adenocarcinoma

Abstract excerpt

Ubiquitin specific protease 4 (USP4) is a member of the USPs family, which catalyzes the cleavage of ubiquitin from a series of protein substrates, thereby modulating a number of cellular signaling pathways. In this study, we aimed to explore the expression profile of USP4 in lung adenocarcinoma (LUAD) using large patient cohorts in the Cancer Genome Atlas and the International Cancer Genome Consortium and to...

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• Autophagy in Disease and Therapy
• Epigenetics and DNA Methylation
• Ubiquitin and proteasome pathways