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Article

RNF4-Dependent Oncogene Activation by Protein Stabilization

1 Sept 2016

Abstract excerpt

Ubiquitylation regulates signaling pathways critical for cancer development and, in many cases, targets proteins for degradation. Here, we report that ubiquitylation by RNF4 stabilizes otherwise short-lived oncogenic transcription factors, including β-catenin, Myc, c-Jun, and the Notch intracellular-domain (N-ICD) protein. RNF4 enhances the transcriptional activity of these factors, as well as Wnt- and...

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PMID: 27653698
DOI: 10.1016/j.celrep.2016.08.024

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