Article
HLA-A, -B, -C, -DRB1 allele and haplotype frequencies of the Korean population and performance characteristics of HLA typing by next-generation sequencing.
HLA - 1 Mar 2021
Jekarl Dong Wook, Lee Gun Dong, Yoo Jae Bin, Kim Jung Rok, Yu Haein, Yoo Jaeeun, Lim Jihyang, Kim Myungshin, Kim Yonggoo
Abstract excerpt
INTRODUCTION: Human leukocyte antigen (HLA) identification at the allelic level is important for haematopoietic stem cell transplantation (HSCT). Next-generation sequencing (NGS) resolves ambiguous alleles by determining the phase of the polymorphisms. The aim of this study was to validate the software for HLA-SBT (sequence-based typing), assess Korean allele frequency, and characterise the performance of NGS-HLA...
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