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Article

H-Ras Isoform Mediates Protection Against Pressure Overload-Induced Cardiac Dysfunction in Part Through Activation of AKT.

Circulation. Heart failure - 1 Feb 2017

Matsuda Takahisa, Jeong Jae Im, Ikeda Shohei, Yamamoto Takanobu, Gao Shumin, Babu Gopal J, Zhai Peiyong, Del Re Dominic P

Abstract excerpt

BACKGROUND: In general, Ras proteins are thought to promote cardiac hypertrophy, an important risk factor for cardiovascular disease and heart failure. However, the contribution of different Ras isoforms has not been investigated. The objective of this study was to define the role of H- and K-Ras in modulating stress-induced myocardial hypertrophy and failure. METHODS AND RESULTS: We used H- and K-Ras gene...

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Identifiers

PMID: 28193718
DOI: 10.1161/CIRCHEARTFAILURE.116.003658
PMCID: PMC5325037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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