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Article

Myocardial KRAS(G12D) expression does not cause cardiomyopathy in mice.

Cardiovascular research - 1 Feb 2014

Dalin Martin G, Zou Zhiyuan, Scharin-Täng Margareta, Safari Roghaiyeh, Karlsson Christin, Bergo Martin O

Abstract excerpt

AIMS: Germ-line mutations in genes encoding components of the RAS/mitogen-activated protein kinase (MAPK) pathway cause developmental disorders called RASopathies. Hypertrophic cardiomyopathy (HCM) is the most common myocardial pathology and a leading cause of death in RASopathy patients. KRAS mutations are found in Noonan and cardio-facio-cutaneous syndromes. KRAS mutations, unlike mutations of RAF1 and HRAS,...

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Source

Identifiers

PMID: 24259500
DOI: 10.1093/cvr/cvt260

Genes

KRAS
HRAS
RAF1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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