Article
First insight into the somatic mutation burden of neurofibromatosis type 2-associated grade I and grade II meningiomas: a case report comprehensive genomic study of two cranial meningiomas with vastly different clinical presentation.
BMC cancer - 13 Feb 2017
Dewan Ramita, Pemov Alexander, Dutra Amalia S, Pak Evgenia D, Edwards Nancy A, Ray-Chaudhury Abhik, Hansen Nancy F, Chandrasekharappa Settara C, Mullikin James C, Asthagiri Ashok R, Heiss John D, Stewart Douglas R, Germanwala Anand V
Abstract excerpt
BACKGROUND: Neurofibromatosis type 2 (NF2) is a rare autosomal dominant nervous system tumor predisposition disorder caused by constitutive inactivation of one of the two copies of NF2. Meningiomas affect about one half of NF2 patients, and are associated with a higher disease burden. Currently, the somatic mutation landscape in NF2-associated meningiomas remains largely unexamined. CASE PRESENTATION: Here, we...
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