Comprehensive genomic analysis of sporadic multiple meningiomas reveals clonal origin and histotype-specific evolution: a case report

Abstract excerpt

<title>Abstract</title> <p>Meningioma is the most common primary intracranial tumor in adults, with up to 10% manifesting as multiple tumors. Data on the genomic and molecular changes in sporadic multiple meningiomas are scarce, leading to ongoing debates regarding their evolutionary processes. A comprehensive genetic analysis of a large number of lesions, including minute occult meningiomas (MOMs), is necessary...

Topics

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• Chromosomes, Human, Pair 22
• Clonal Evolution
• CREB-Binding Protein
• Exome Sequencing
• INDEL Mutation
• Meningeal Neoplasms
• Meningioma
• Neurofibromin 2

Identifiers and source

Literature Corpus work

a9435e4f-087f-54ba-b57a-9bb3a0bf807e

DOI

10.21203/rs.3.rs-4183469/v1