Article
Comprehensive genomic analysis reveals clonal origin and subtype-specific evolution in a case of sporadic multiple meningiomas.
Brain tumor pathology - 1 Oct 2024
Sakaguchi Maki, Horie Masafumi, Ito Yukinobu, Tanaka Shingo, Mizuguchi Keishi, Ikeda Hiroko, Kiyokawa Etsuko, Nakada Mitsutoshi, Maeda Daichi
Abstract excerpt
Meningioma is the most common primary intracranial tumor in adults, with up to 10% manifesting as multiple tumors. Data on the genomic and molecular changes in sporadic multiple meningiomas are scarce, leading to ongoing debates regarding their evolutionary processes. A comprehensive genetic analysis of a large number of lesions, including precursor lesions, is necessary to explore these two possible origins:...
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