Article
Genomic landscape of intracranial meningiomas.
Journal of neurosurgery - 1 Sept 2016
Bi Wenya Linda, Abedalthagafi Malak, Horowitz Peleg, Agarwalla Pankaj K, Mei Yu, Aizer Ayal A, Brewster Ryan, Dunn Gavin P, Al-Mefty Ossama, Alexander Brian M, Santagata Sandro, Beroukhim Rameen, Dunn Ian F
Abstract excerpt
Meningiomas are the most common primary intracranial neoplasms in adults. Current histopathological grading schemes do not consistently predict their natural history. Classic cytogenetic studies have disclosed a progressive course of chromosomal aberrations, especially in high-grade meningiomas. Furthermore, the recent application of unbiased next-generation sequencing approaches has implicated several novel...
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