Article
Exome sequencing on malignant meningiomas identified mutations in neurofibromatosis type 2 (NF2) and meningioma 1 (MN1) genes.
Discovery medicine - 1 Dec 2014
Zhang Xu, Jia Haiying, Lu Yao, Dong Chengliang, Hou Jinghui, Wang Zheng, Wang Feng, Zhong Hongbin, Wang Lin, Wang Kai
Abstract excerpt
BACKGROUND: Meningiomas are tumors originating from the membranous layers surrounding the central nervous system, and are generally regarded as "benign" tumors of the brain. Malignant meningiomas are rare and are typically associated with a higher risk of local tumor recurrence and a poorer prognosis (median survival time <2 years). Previous genome-wide association studies and exome sequencing studies have...
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