Article
Comparative clinical and genomic analysis of neurofibromatosis type 2-associated cranial and spinal meningiomas.
Scientific reports - 28 Jul 2020
Pemov Alexander, Dewan Ramita, Hansen Nancy F, Chandrasekharappa Settara C, Ray-Chaudhury Abhik, Jones Kristine, Luo Wen, Heiss John D, Mullikin James C, Chittiboina Prashant, Stewart Douglas R, Asthagiri Ashok R
Abstract excerpt
Neurofibromatosis type 2 (NF2) is an autosomal dominant Mendelian tumor predisposition disorder caused by germline pathogenic variants in the tumor suppressor NF2. Meningiomas are the second most common neoplasm in NF2, often occurring in multiple intracranial and spinal locations within the same patient. In this prospective longitudinal study, we assessed volumes and growth rates of ten spinal and ten cranial...
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