Article
Integrated genomic analyses of de novo pathways underlying atypical meningiomas.
Nature communications - 14 Feb 2017
Harmancı Akdes Serin, Youngblood Mark W, Clark Victoria E, Coşkun Süleyman, Henegariu Octavian, Duran Daniel, Erson-Omay E Zeynep, Kaulen Leon D, Lee Tong Ihn, Abraham Brian J, Simon Matthias, Krischek Boris, Timmer Marco, Goldbrunner Roland, Omay S Bülent, Baranoski Jacob, Baran Burçin, Carrión-Grant Geneive, Bai Hanwen, Mishra-Gorur Ketu, Schramm Johannes, Moliterno Jennifer, Vortmeyer Alexander O, Bilgüvar Kaya, Yasuno Katsuhito, Young Richard A, Günel Murat
Abstract excerpt
Meningiomas are mostly benign brain tumours, with a potential for becoming atypical or malignant. On the basis of comprehensive genomic, transcriptomic and epigenomic analyses, we compared benign meningiomas to atypical ones. Here, we show that the majority of primary (de novo) atypical meningiomas display loss of NF2, which co-occurs either with genomic instability or recurrent SMARCB1 mutations. These tumours...
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