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Article

Aberrant Transforming Growth Factor-β Activation Recruits Mesenchymal Stem Cells During Prostatic Hyperplasia.

Stem cells translational medicine - 1 Feb 2017

Wang Long, Xie Liang, Tintani Francis, Xie Hui, Li Changjun, Cui Zhuang, Wan Mei, Zu Xiongbing, Qi Lin, Cao Xu

Abstract excerpt

Benign prostatic hyperplasia (BPH) is the overgrowth of prostate tissues with high prevalence in older men. BPH pathogenesis is not completely understood, but it is believed to be a result of de novo overgrowth of prostatic stroma. In this study, we show that aberrant activation of transforming growth factor-β (TGF-β) mobilizes mesenchymal/stromal stem cells (MSCs) in circulating blood, which are recruited for...

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Identifiers

PMID: 28191756
DOI: 10.5966/sctm.2015-0411
PMCID: PMC5442798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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