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Stromal androgen signaling governs essential niches in supporting prostate development and tumorigenesis

5 Oct 2024

Abstract excerpt

Androgens and androgen receptor (AR) mediated signaling pathways are essential for prostate development, morphogenesis, growth, and regeneration. Early tissue recombination experiments showed that AR-deficient urogenital sinus mesenchyme combined with intact urogenital sinus epithelium failed to develop into a prostate, demonstrating a stem cell niche for mesenchymal AR in prostatic development. Androgen...

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PMID: 39369165
DOI: 10.1038/s41388-024-03175-1

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