Article
A Population Genomics Approach to Assessing the Genetic Basis of Within-Host Microevolution Underlying Recurrent Cryptococcal Meningitis Infection.
G3 (Bethesda, Md.) - 3 Apr 2017
Rhodes Johanna, Beale Mathew A, Vanhove Mathieu, Jarvis Joseph N, Kannambath Shichina, Simpson John A, Ryan Anthea, Meintjes Graeme, Harrison Thomas S, Fisher Matthew C, Bicanic Tihana
Abstract excerpt
Recurrence of meningitis due to Cryptococcus neoformans after treatment causes substantial mortality in HIV/AIDS patients across sub-Saharan Africa. In order to determine whether recurrence occurred due to relapse of the original infecting isolate or reinfection with a different isolate weeks or months after initial treatment, we used whole-genome sequencing (WGS) to assess the genetic basis of infection in 17...
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