Article
Microevolution of Serial Clinical Isolates of Cryptococcus neoformans var. grubii and C. gattii.
mBio - 7 Mar 2017
Chen Yuan, Farrer Rhys A, Giamberardino Charles, Sakthikumar Sharadha, Jones Alexander, Yang Timothy, Tenor Jennifer L, Wagih Omar, Van Wyk Marelize, Govender Nelesh P, Mitchell Thomas G, Litvintseva Anastasia P, Cuomo Christina A, Perfect John R
Abstract excerpt
The pathogenic species of Cryptococcus are a major cause of mortality owing to severe infections in immunocompromised as well as immunocompetent individuals. Although antifungal treatment is usually effective, many patients relapse after treatment, and in such cases, comparative analyses of the genomes of incident and relapse isolates may reveal evidence of determinative, microevolutionary changes within the...
Topics
- Adaptation, Biological
- Cerebrospinal Fluid
- Cryptococcus gattii
- Cryptococcus neoformans
- Drug Resistance, Fungal
- Evolution, Molecular
- Genotype
- Humans
- Longitudinal Studies
- Meningitis, Cryptococcal
- Phenotype
- Recurrence