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Role of Pore-Forming Toxins in Bacterial Infectious Diseases

22 May 2013

Abstract excerpt

Pore-forming toxins (PFTs) are the most common bacterial cytotoxic proteins and are required for virulence in a large number of important pathogens, including Streptococcus pneumoniae, group A and B streptococci, Staphylococcus aureus, Escherichia coli, and Mycobacterium tuberculosis. PFTs generally disrupt host cell membranes, but they can have additional effects independent of pore formation. Substantial effort...

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PMID: 23699254
DOI: 10.1128/mmbr.00052-12

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