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Article

Host-Derived Microvesicles Carrying Bacterial Pore-Forming Toxins Deliver Signals to Macrophages: A Novel Mechanism of Shaping Immune Responses.

Frontiers in immunology - 1 Jan 2018

Köffel René, Wolfmeier Heidi, Larpin Yu, Besançon Hervé, Schoenauer Roman, Babiychuk Viktoria S, Drücker Patrick, Pabst Thomas, Mitchell Timothy J, Babiychuk Eduard B, Draeger Annette

Abstract excerpt

Bacterial infectious diseases are a leading cause of death. Pore-forming toxins (PFTs) are important virulence factors of Gram-positive pathogens, which disrupt the plasma membrane of host cells and can lead to cell death. Yet, host defense and cell membrane repair mechanisms have been identified: i.e., PFTs can be eliminated from membranes as microvesicles, thus limiting the extent of cell damage. Released into...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30100903
DOI: 10.3389/fimmu.2018.01688
PMCID: PMC6072879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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