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Article

Elimination of a bacterial pore-forming toxin by sequential endocytosis and exocytosis.

FEBS letters - 22 Jan 2009

Husmann Matthias, Beckmann Erik, Boller Klaus, Kloft Nicole, Tenzer Stefan, Bobkiewicz Wiesia, Neukirch Claudia, Bayley Hagan, Bhakdi Sucharit

Abstract excerpt

Staphylococcus aureus alpha-toxin is the archetype of bacterial pore forming toxins and a key virulence factor secreted by the majority of clinical isolates of S. aureus. Toxin monomers bind to target cells and oligomerize to form small beta-barrel pores in the plasma membrane. Many nucleated cells are able to repair a limited number of lesions by unknown, calcium-independent mechanisms. Here we show that cells...

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Identifiers

PMID: 19101547
DOI: 10.1016/j.febslet.2008.12.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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