Article
Cytolysin-dependent evasion of lysosomal killing.
Proceedings of the National Academy of Sciences of the United States of America - 5 Apr 2005
Håkansson Anders, Bentley Colette Cywes, Shakhnovic Elizabeth A, Wessels Michael R
Abstract excerpt
Local host defenses limit proliferation and systemic spread of pathogenic bacteria from sites of mucosal colonization. For pathogens such as streptococci that fail to grow intracellularly, internalization and killing by epithelial cells contribute to the control of bacterial growth and dissemination. Here, we show that group A Streptococcus (GAS), the agent of streptococcal sore throat and invasive soft tissue...
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