Article
Low expression of ASH2L protein correlates with a favorable outcome in acute myeloid leukemia.
Leukemia & lymphoma - 1 May 2017
Butler Jill S, Qiu Yi Hua, Zhang Nianxiang, Yoo Suk-Young, Coombes Kevin R, Dent Sharon Y R, Kornblau Steven M
Abstract excerpt
ASH2L encodes a trithorax group protein that is a core component of all characterized mammalian histone H3K4 methyltransferase complexes, including mixed lineage leukemia (MLL) complexes. ASH2L protein levels in primary leukemia patient samples have not yet been defined. We analyzed ASH2L protein expression in 511 primary AML patient samples using reverse phase protein array (RPPA) technology. We discovered that...
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