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Article

Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding.

EMBO reports - 10 Jun 2011

Chen Yong, Wan Bingbing, Wang Kevin C, Cao Fang, Yang Yuting, Protacio Angeline, Dou Yali, Chang Howard Y, Lei Ming

Abstract excerpt

Ash2L is a core component of the MLL family histone methyltransferases and has an important role in regulating the methylation of histone H3 on lysine 4. Here, we report the crystal structure of the N-terminal domain of Ash2L and reveal a new function of Ash2L. The structure shows that Ash2L cont...

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Identifiers

PMID: 21660059
DOI: 10.1038/embor.2011.101
PMCID: PMC3147254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21660059-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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