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Article

ASB-2 Inhibits Growth and Promotes Commitment in Myeloid Leukemia Cells

1 Jan 2002

Abstract excerpt

In acute promyelocytic leukemia (APL) cells harboring the promyelocytic leukemia retinoic acid receptor alpha (PML-RARalpha) chimeric protein, retinoic acid (RA)-induced differentiation is triggered through a PML-RARalpha signaling resulting in activation of critical target genes. Induced differentiation of APL cells is always preceded by withdrawal from the cell cycle and commitment events leading to terminal...

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PMID: 11682484
DOI: 10.1074/jbc.m108476200

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