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Article

IL2RA Promotes Aggressiveness and Stem Cell–Related Properties of Acute Myeloid Leukemia

1 Sept 2020

Abstract excerpt

Abstract Overexpression of IL2RA, which encodes the alpha chain of the IL2 receptor, is associated with chemotherapy resistance and poor outcome in acute myeloid leukemia (AML). The clinical potential of anti-IL2RA therapy is, therefore, being explored in early-stage clinical trials. Notwithstanding, only very limited information regarding the biological function of IL2RA in AML is available. Using genetic...

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PMID: 32873636
DOI: 10.1158/0008-5472.can-20-0531

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