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Article

Tell-Tale SNPs: The Role of CYP2B6 in Methadone Fatalities.

Journal of analytical toxicology - 1 May 2017

Ahmad Taha, Sabet Samie, Primerano Donald A, Richards-Waugh Lauren L, Rankin Gary O

Abstract excerpt

Cytochrome P450 (CYP) enzyme 2B6 plays a significant role in the stereo-selective metabolism of (S)-methadone to 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine, an inactive methadone metabolite. Elevated (S)-methadone can cause cardiotoxicity by prolonging the QT interval of the heart's electrical cycle. Large inter-individual variability of methadone pharmacokinetics causes discordance in the relationship between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 28184434
DOI: 10.1093/jat/bkw135
PMCID: PMC5412025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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