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Article

Fatal methadone toxicity: potential role of CYP3A4 genetic polymorphism.

Journal of analytical toxicology - 1 Oct 2014

Richards-Waugh Lauren L, Primerano Donald A, Dementieva Yulia, Kraner James C, Rankin Gary O

Abstract excerpt

Methadone is difficult to administer as a therapeutic agent because of a wide range of interindividual pharmacokinetics, likely due to genetic variability of the CYP450 enzymes responsible for metabolism to its principal metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP). CYP3A4 is one of the primary CYP450 isoforms responsible for the metabolism of methadone to EDDP in humans. The purpose of...

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Identifiers

PMID: 25217544
DOI: 10.1093/jat/bku091
PMCID: PMC4229888

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