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Article

CYP2B6 and OPRM1 gene variations predict methadone-related deaths.

Addiction biology - 1 Jan 2011

Bunten Hannah, Liang Wei-Jun, Pounder Derrick, Seneviratne Collin, Osselton Michael David

Abstract excerpt

The largest proportion of methadone-associated deaths occurs during the drug induction phase. We analysed methadone-related fatalities for gene variations linked with methadone action. A significant association between high methadone concentrations and the CYP2B6*6 allele characteristic of the slow metabolizer phenotype was identified. We suggest that the risk of methadone fatality may be predetermined in part by...

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Source

Identifiers

PMID: 21158011
DOI: 10.1111/j.1369-1600.2010.00274.x

Genes

OPRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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