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Article

OPRM1 and CYP2B6 gene variants as risk factors in methadone-related deaths.

Clinical pharmacology and therapeutics - 1 Sept 2010

Bunten H, Liang W J, Pounder D J, Seneviratne C, Osselton D

Abstract excerpt

Methadone is a medication valued for its effectiveness in the treatment of heroin addiction; however, many fatal poisonings associated with its use have been reported over the years. We have examined the association between CYP2B6 and micro-opioid receptor (OPRM1) gene variations and apparent susceptibility to methadone poisoning. Genomic DNA was extracted from postmortem whole blood of 40 individuals whose...

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Share to Analgesics, Opioid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20668445
DOI: 10.1038/clpt.2010.127

Genes

OPRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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