Role of MRE11 in Cell Proliferation, Tumor Invasion, and DNA Repair in Breast Cancer

Abstract excerpt

BACKGROUND: Previous studies have shown that altered forms of MRE11, a protein known to play a vital role in DNA double-strand break repair, DNA replication, and telomere maintenance are associated with cancer outcomes. We investigated the role of MRE11 in breast cancer in both clinical and in vitro settings. METHODS: We examined MRE11 expression in tumor tissues from invasive ductal carcinoma breast cancer...

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