Article
DEAR1 is a dominant regulator of acinar morphogenesis and an independent predictor of local recurrence-free survival in early-onset breast cancer.
PLoS medicine - 26 May 2009
Lott Steven T, Chen Nanyue, Chandler Dawn S, Yang Qifeng, Wang Luo, Rodriguez Marivonne, Xie Hongyan, Balasenthil Seetharaman, Buchholz Thomas A, Sahin Aysegul A, Chaung Katrina, Zhang Baili, Olufemi Shodimu-Emmanu, Chen Jinyun, Adams Henry, Band Vimla, El-Naggar Adel K, Frazier Marsha L, Keyomarsi Khandan, Hunt Kelly K, Sen Subrata, Haffty Bruce, Hewitt Stephen M, Krahe Ralf, Killary Ann McNeill
Abstract excerpt
BACKGROUND: Breast cancer in young women tends to have a natural history of aggressive disease for which rates of recurrence are higher than in breast cancers detected later in life. Little is known about the genetic pathways that underlie early-onset breast cancer. Here we report the discovery of DEAR1 (ductal epithelium-associated RING Chromosome 1), a novel gene encoding a member of the TRIM (tripartite motif)...
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