Article
Role of the oxidized form of XRCC1 in protection against extreme oxidative stress.
Free radical biology & medicine - 1 Jun 2017
Horton Julie K, Seddon Hannah J, Zhao Ming-Lang, Gassman Natalie R, Janoshazi Agnes K, Stefanick Donna F, Wilson Samuel H
Abstract excerpt
The multi-domain protein XRCC1 is without catalytic activity, but can interact with a number of known repair proteins. The interaction between the N-terminal domain (NTD) of XRCC1 and DNA polymerase β (pol β) is critical for recruitment of pol β to sites of DNA damage and repair. Crystallographic and NMR approaches have identified oxidized and reduced forms of the XRCC1 NTD, and the corresponding forms of XRCC1...
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