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Article

The region of XRCC1 which harbours the three most common nonsynonymous polymorphic variants, is essential for the scaffolding function of XRCC1.

DNA repair - 1 Apr 2012

Hanssen-Bauer Audun, Solvang-Garten Karin, Gilljam Karin Margaretha, Torseth Kathrin, Wilson David M, Akbari Mansour, Otterlei Marit

Abstract excerpt

XRCC1 functions as a non-enzymatic, scaffold protein in single strand break repair (SSBR) and base excision repair (BER). Here, we examine different regions of XRCC1 for their contribution to the scaffolding functions of the protein. We found that the central BRCT1 domain is essential for recruitment of XRCC1 to sites of DNA damage and DNA replication. Also, we found that ectopic expression of the region from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22281126
DOI: 10.1016/j.dnarep.2012.01.001
PMCID: PMC3319167

Genes

XRCC1
PNKP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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