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Article

Interaction with OGG1 is required for efficient recruitment of XRCC1 to base excision repair and maintenance of genetic stability after exposure to oxidative stress.

Molecular and cellular biology - 1 May 2015

Campalans Anna, Moritz Eva, Kortulewski Thierry, Biard Denis, Epe Bernd, Radicella J Pablo

Abstract excerpt

XRCC1 is an essential protein required for the maintenance of genomic stability through its implication in DNA repair. The main function of XRCC1 is associated with its role in the single-strand break (SSB) and base excision repair (BER) pathways that share several enzymatic steps. We show here that the polymorphic XRCC1 variant R194W presents a defect in its interaction with the DNA glycosylase OGG1 after...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25733688
DOI: 10.1128/MCB.00134-15
PMCID: PMC4387214

Genes

XRCC1
OGG1
SSB

Variants

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