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Article

Beluga whale pVHL enhances HIF-2α activity via inducing HIF-2α proteasomal degradation under hypoxia.

Oncotarget - 27 Jun 2017

Bi Jianling, Hu Bo, Wang Jing, Liu Xing, Zheng Jinsong, Wang Ding, Xiao Wuhan

Abstract excerpt

Aquatic mammals, such as cetaceans experience various depths, with accordingly diverse oxygenation, thus, cetaceans have developed adaptations for hypoxia, but mechanisms underlying this tolerance to low oxygen are unclear. Here we analyzed VHL and HIF-2α, in the hypoxia signaling pathway. Variations in VHL are greater than HIF-2α between cetaceans and terrestrial mammals, and beluga whale VHL (BW-VHL) promotes...

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Share to Basic Helix-Loop-Helix Transcription Factors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proteasome Endopeptidase Complex

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Source

Open in PubMed Open full text

Identifiers

PMID: 28178687
DOI: 10.18632/oncotarget.15038
PMCID: PMC5522066

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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