Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DUX4c Is Up-Regulated in FSHD. It Induces the MYF5 Protein and Human Myoblast Proliferation

14 Oct 2009

Abstract excerpt

Facioscapulohumeral muscular dystrophy (FSHD) is a dominant disease linked to contractions of the D4Z4 repeat array in 4q35. We have previously identified a double homeobox gene (DUX4) within each D4Z4 unit that encodes a transcription factor expressed in FSHD but not control myoblasts. DUX4 and its target genes contribute to the global dysregulation of gene expression observed in FSHD. We have now characterized...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Muscle Physiology and Disorders
Share to Neurogenetic and Muscular Disorders Research
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19829708
DOI: 10.1371/journal.pone.0007482

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DUX4c Is Up-Regulated in FSHD. It Induces the MYF5 Protein and Human Myoblast ProliferationPMID 19829708Read ↗

Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei.Semantic proximity Read ↗

DUX4 induces a transcriptome more characteristic of a less-differentiated cell state and inhibits myogenesisSemantic proximity Read ↗

Antagonism Between DUX4 and DUX4c Highlights a Pathomechanism Operating Through β-Catenin in Facioscapulohumeral Muscular DystrophySemantic proximity Read ↗

DUX4 Differentially Regulates Transcriptomes of Human Rhabdomyosarcoma and Mouse C2C12 CellsSemantic proximity Read ↗

DUX4 at 25: how it emerged from “junk DNA” to become the cause of facioscapulohumeral muscular dystrophySemantic proximity Read ↗

The FSHD atrophic myotube phenotype is caused by DUX4 expression.Semantic proximity Read ↗

Biphasic myopathic phenotype of mouse DUX, an ORF within conserved FSHD-related repeats.Semantic proximity Read ↗

Facioscapulohumeral muscular dystrophy: molecular pathological advances and future directions.Semantic proximity Read ↗

Influence of DUX4 Expression in Facioscapulohumeral Muscular Dystrophy and Possible TreatmentsSemantic proximity Read ↗

Increased DUX4 expression during muscle differentiation correlates with decreased SMCHD1 protein levels at D4Z4Semantic proximity Read ↗

Genetic and epigenetic characteristics of FSHD-associated 4q and 10q D4Z4 that are distinct from non-4q/10q D4Z4 homologs.Semantic proximity Read ↗

Gene expression during normal and FSHD myogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.