Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of PARP activity in lung cancer-induced cachexia: Effects on muscle oxidative stress, proteolysis, anabolic markers, and phenotype.

Journal of cellular physiology - 1 Dec 2017

Chacon-Cabrera Alba, Mateu-Jimenez Mercè, Langohr Klaus, Fermoselle Clara, García-Arumí Elena, Andreu Antoni L, Yelamos Jose, Barreiro Esther

Abstract excerpt

Strategies to treat cachexia are still at its infancy. Enhanced muscle protein breakdown and ubiquitin-proteasome system are common features of cachexia associated with chronic conditions including lung cancer (LC). Poly(ADP-ribose) polymerases (PARP), which play a major role in chromatin structure regulation, also underlie maintenance of muscle metabolism and body composition. We hypothesized that protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cachexia
Share to Diaphragm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, 129 Strain

Share to Mitochondria, Muscle

Share to Muscle Fibers, Skeletal

Share to Poly (ADP-Ribose) Polymerase-1

Share to Poly(ADP-ribose) Polymerases

Share to Ubiquitination

Source

Identifiers

PMID: 28177129
DOI: 10.1002/jcp.25851

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of PARP activity in lung cancer-induced cachexia: Effects on muscle oxidative stress, proteolysis, anabolic markers, and phenotype.PMID 28177129Read ↗

Integrative study of skeletal muscle mitochondrial dysfunction in a murine pancreatic cancer-induced cachexia modelSemantic proximity Read ↗

Phenotypic and metabolic features of mouse diaphragm and gastrocnemius muscles in chronic lung carcinogenesis: influence of underlying emphysema.Semantic proximity Read ↗

Curcumin and Resveratrol Improve Muscle Function and Structure through Attenuation of Proteolytic Markers in Experimental Cancer-Induced Cachexia.Semantic proximity Read ↗

Tumor-induced alterations in single-nucleus transcriptome of atrophying muscles indicate enhanced protein degradation and reduced oxidative metabolismSemantic proximity Read ↗

Distinct cachexia profiles in response to human pancreatic tumours in mouse limb and respiratory muscleSemantic proximity Read ↗

The canonical ER stress IRE1α/XBP1 pathway mediates skeletal muscle wasting during pancreatic cancer cachexiaSemantic proximity Read ↗

Upregulation of ubiquitinated proteins and their degradation pathway in muscle atrophy induced by cisplatin in miceSemantic proximity Read ↗

Cancer Cachexia Signaling Pathways Continue to Emerge Yet Much Still Points to the ProteasomeSemantic proximity Read ↗

Transcriptomic analysis of the development of skeletal muscle atrophy in cancer-cachexia in tumor-bearing miceSemantic proximity Read ↗

Photobiomodulation Therapy Moderates Cancer Cachexia-associated Muscle wasting through Activating PI3K/AKT/FoxO3a Pathway succinct title: PBMT Alleviates Muscle Wasting via PI3K/AKT/FoxO3a PathwaySemantic proximity Read ↗

PARP1 mediated PARylation contributes to myogenic progression and glucocorticoid transcriptional response.Semantic proximity Read ↗

Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour-bearing mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.