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Article

Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour-bearing mice.

Journal of cachexia, sarcopenia and muscle - 1 Dec 2017

Brown Jacob L, Rosa-Caldwell Megan E, Lee David E, Blackwell Thomas A, Brown Lemuel A, Perry Richard A, Haynie Wesley S, Hardee Justin P, Carson James A, Wiggs Michael P, Washington Tyrone A, Greene Nicholas P

Abstract excerpt

BACKGROUND: Cancer cachexia is largely irreversible, at least via nutritional means, and responsible for 20-40% of cancer-related deaths. Therefore, preventive measures are of primary importance; however, little is known about muscle perturbations prior to onset of cachexia. Cancer cachexia is associated with mitochondrial degeneration; yet, it remains to be determined if mitochondrial degeneration precedes...

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Identifiers

PMID: 28845591
DOI: 10.1002/jcsm.12232
PMCID: PMC5700433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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