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Article

Comparison of phenotypic and transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and Ppara-null mouse livers.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jul 2025

Heintz Melissa M, Buerger Amanda N, Haws Laurie C, Cullen John M, East Alexander W, Thompson Chad M

Abstract excerpt

Recent in vitro transcriptomic analyses for short-chain per- and polyfluoroalkyl substances HFPO-DA (ammonium, 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate) added to the weight of evidence supporting the peroxisome proliferator-activated receptor alpha (PPARα) activator-induced hepatocarcinogenesis mode of action (MOA) for HFPO-DA-mediated liver effects in rodents. Importantly, PPARα-mediated key events...

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Acetaminophen
Butyrates
Phenylurea Compounds
PPAR alpha
PPAR gamma

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PMID: 40216583
DOI: 10.1093/toxsci/kfaf049
PMCID: PMC12198672

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