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Article

Functional importance of stripping in NFκB signaling revealed by a stripping-impaired IκBα mutant.

Proceedings of the National Academy of Sciences of the United States of America - 21 Feb 2017

Dembinski Holly E, Wismer Kevin, Vargas Jesse D, Suryawanshi Gajendra W, Kern Nadja, Kroon Gerard, Dyson H Jane, Hoffmann Alexander, Komives Elizabeth A

Abstract excerpt

Stress-response transcription factors such as NFκB turn on hundreds of genes and must have a mechanism for rapid cessation of transcriptional activation. We recently showed that the inhibitor of NFκB signaling, IκBα, dramatically accelerates the dissociation of NFκB from transcription sites, a process we have called "stripping." To test the role of the IκBα C-terminal PEST (rich in proline, glutamic acid, serine,...

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Identifiers

PMID: 28167786
DOI: 10.1073/pnas.1610192114
PMCID: PMC5338396

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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