Coordination of a transcriptional switch by HMGI(Y) acetylation.

doi:10.1126/science.293.5532.1133

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Article

Coordination of a transcriptional switch by HMGI(Y) acetylation.

Science (New York, N.Y.) - 10 Aug 2001

Munshi N, Agalioti T, Lomvardas S, Merika M, Chen G, Thanos D

Abstract excerpt

Dynamic control of interferon-beta (IFN-beta) gene expression requires the regulated assembly and disassembly of the enhanceosome, a higher-order nucleoprotein complex formed in response to virus infection. The enhanceosome activates transcription by recruiting the histone acetyltransferase proteins CREB binding protein (CBP) and p300/CBP-associated factors (PCAF)/GCN5, which, in addition to modifying histones,...

Topics

Acetylation
Acetyltransferases
Amino Acid Sequence
CREB-Binding Protein
Cell Cycle Proteins
Enhancer Elements, Genetic
Gene Expression Regulation
HMGA1a Protein
HeLa Cells
High Mobility Group Proteins
Histone Acetyltransferases
Histones
Humans

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interferon-beta

Lysine

Molecular Sequence Data

Mutation

Nuclear Proteins

Source

Open in PubMed

Identifiers

PMID: 11498590
DOI: 10.1126/science.293.5532.1133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.