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Article

Coordination of a transcriptional switch by HMGI(Y) acetylation.

Science (New York, N.Y.) - 10 Aug 2001

Munshi N, Agalioti T, Lomvardas S, Merika M, Chen G, Thanos D

Abstract excerpt

Dynamic control of interferon-beta (IFN-beta) gene expression requires the regulated assembly and disassembly of the enhanceosome, a higher-order nucleoprotein complex formed in response to virus infection. The enhanceosome activates transcription by recruiting the histone acetyltransferase proteins CREB binding protein (CBP) and p300/CBP-associated factors (PCAF)/GCN5, which, in addition to modifying histones,...

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Source

Identifiers

PMID: 11498590
DOI: 10.1126/science.293.5532.1133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Coordination of a transcriptional switch by HMGI(Y) acetylation.PMID 11498590Read ↗

The role of HMG I(Y) in the assembly and function of the IFN-beta enhanceosome.Semantic proximity Read ↗

Histone H2A.Z Suppression of Interferon-Stimulated Transcription and Antiviral Immunity Is Modulated by GCN5 and BRD2Semantic proximity Read ↗

Orchestration of protein acetylation as a toggle for cellular defense and virus replicationSemantic proximity Read ↗

Epigenetic and transcriptional control of interferon-βSemantic proximity Read ↗

Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major histocompatibility complex class II genes.Semantic proximity Read ↗

Promoter-specific changes in initiation, elongation and homeostasis of histone H3 acetylation during CBP/p300 InhibitionSemantic proximity Read ↗

Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunitySemantic proximity Read ↗

Interactions between p300 and multiple NF-Y trimers govern cyclin B2 promoter function.Semantic proximity Read ↗

A role for the architectural transcription factors HMGI(Y) in cytokine gene transcription in T cells.Semantic proximity Read ↗

Assembly of a Functional Beta Interferon Enhanceosome Is Dependent on ATF-2–c-jun Heterodimer OrientationSemantic proximity Read ↗

Mechanism for specificity by HMG-1 in enhanceosome assembly.Semantic proximity Read ↗

Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In VivoSemantic proximity Read ↗

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