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Article

A mutant Rel-homology domain promotes transcription by p50/NFkappaB1.

Oncogene - 3 Apr 1997

Xu X, Gélinas C

Abstract excerpt

Previous studies showed that the binding of p50/NFkappaB1 to particular kappaB DNA sites altered its conformation in a way that correlated with transcriptional activation. Here, we investigated the effects of protein-protein interactions on the transcriptional activity of p50. We show that the association of p50 with a mutant Rel-homology domain (RHD) defective for DNA binding led to synergistic activation of...

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Source

Identifiers

PMID: 9129142
DOI: 10.1038/sj.onc.1200985

Genes

RHD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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