Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IκBα Nuclear Export Enables 4-1BB-Induced cRel Activation and IL-2 Production to Promote CD8 T Cell Immunity.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2020

Lisiero Dominique N, Cheng Zhang, Tejera Melba M, Neldner Brandon T, Warrick Jay W, Wuerzberger-Davis Shelly M, Hoffmann Alexander, Suresh M, Miyamoto Shigeki

Abstract excerpt

Optimal CD8 T cell immunity is orchestrated by signaling events initiated by TCR recognition of peptide Ag in concert with signals from molecules such as CD28 and 4-1BB. The molecular mechanisms underlying the temporal and spatial signaling dynamics in CD8 T cells remain incompletely understood. In this study, we show that stimulation of naive CD8 T cells with agonistic CD3 and CD28 Abs, mimicking TCR and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Adoptive Transfer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD28 Antigens

Share to CD8-Positive T-Lymphocytes

Share to Interleukin-2

Share to Lymphocyte Activation

Share to NF-KappaB Inhibitor alpha

Share to Receptors, Antigen, T-Cell

Source

Open in PubMed Open full text

Identifiers

PMID: 32817348
DOI: 10.4049/jimmunol.2000039
PMCID: PMC7484350

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IκBα Nuclear Export Enables 4-1BB-Induced cRel Activation and IL-2 Production to Promote CD8 T Cell Immunity.PMID 32817348Read ↗

NF-κB subunits RelA and c-Rel selectively control CD4+ T cell function in multiple sclerosis and cancerSemantic proximity Read ↗

NF-κB: At the Borders of Autoimmunity and Inflammation.Semantic proximity Read ↗

Nfkbie-deficiency leads to increased susceptibility to develop B-cell lymphoproliferative disorders in aged miceSemantic proximity Read ↗

AP-1–independent NFAT signaling maintains follicular T cell function in infection and autoimmunitySemantic proximity Read ↗

Nuclear Factor-kappaB in Autoimmunity: Man and Mouse.Semantic proximity Read ↗

Defective lymphoid organogenesis underlies the immune deficiency caused by a heterozygous S32I mutation in IκBα.Semantic proximity Read ↗

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency.Semantic proximity Read ↗

A Suite of Eight <i>Toxoplasma gondii</i> Effectors Cooperates to Activate the Non-canonical NF-κB PathwaySemantic proximity Read ↗

An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function.Semantic proximity Read ↗

Noncanonical NF-κB signaling is limited by classical NF-κB activity.Semantic proximity Read ↗

NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner.Semantic proximity Read ↗

N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.