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Article

Role of lysine methylation of NF-κB in differential gene regulation.

Proceedings of the National Academy of Sciences of the United States of America - 13 Aug 2013

Lu Tao, Yang Maojing, Huang De-Bin, Wei Han, Ozer Gulcin H, Ghosh Gourisankar, Stark George R

Abstract excerpt

Lysine methylation of the p65 subunit of nuclear factor κB (NF-κB) on K218 and K221 together or K37 alone strongly enhances gene expression in response to cytokines. We analyzed the effects of K-to-Q mutations in the REL homology domain of p65 on the response to IL-1β in 293 cells with low levels...

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Identifiers

PMID: 23904479
DOI: 10.1073/pnas.1311770110
PMCID: PMC3746872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23904479-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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