Article
Involvement of DNA binding domain in the cellular stability and importin affinity of NF-κB component RelB.
Organic & biomolecular chemistry - 21 Apr 2012
Takeiri Masatoshi, Horie Kana, Takahashi Daisuke, Watanabe Mariko, Horie Ryoichi, Simizu Siro, Umezawa Kazuo
Abstract excerpt
NF-κB is a transcription factor for the immune activation and tissue stability, but excess activation of NF-κB often causes inflammation and cancer. An NF-κB component RelB is involved in B-cell maturation and autoimmunity. In the present research we studied the role of the RelB DNA binding domain on cellular stability and importin affinity. We prepared a RelB protein mutated at Arg141 to Ala and Tyr142 to Ala...
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