Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Specification of the NF-kappaB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKK epsilon.

Nucleic acids research - 1 Oct 2010

Moreno Rita, Sobotzik Jürgen-Markus, Schultz Christian, Schmitz M Lienhard

Abstract excerpt

Here we investigated the regulation of NF-κB activity by post-translational modifications upon reconstitution of NF-κB p65-deficient cells with the wild-type protein or phosphorylation-defect mutants. Analysis of NF-κB target gene expression showed that p65 phosphorylations alone or in combination function to direct transcription in a highly target gene-specific fashion, a finding discussed here as the NF-κB...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Cell Nucleus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin

Share to HeLa Cells

Share to I-kappa B Kinase

Share to Phosphorylation

Share to Transcription Factor RelA

Share to Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 20507904
DOI: 10.1093/nar/gkq439
PMCID: PMC2952868

Genes

PML
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Specification of the NF-kappaB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKK epsilon.PMID 20507904Read ↗

Hypo-phosphorylation leads to nuclear retention of NF-kappaB p65 due to impaired IkappaBalpha gene synthesis.Semantic proximity Read ↗

Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription.Semantic proximity Read ↗

IKK epsilon kinase is crucial for viral G protein-coupled receptor tumorigenesisSemantic proximity Read ↗

Phosphorylation of RelA/p65 on serine 536 defines an I{kappa}B{alpha}-independent NF-{kappa}B pathway.Semantic proximity Read ↗

Cross talk between stimulated NF-kappaB and the tumor suppressor p53.Semantic proximity Read ↗

cis-acting, element-specific transcriptional activity of differentially phosphorylated nuclear factor-kappa B.Semantic proximity Read ↗

The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity.Semantic proximity Read ↗

IKKbeta phosphorylates p65 at S468 in transactivaton domain 2.Semantic proximity Read ↗

Thr435 phosphorylation regulates RelA (p65) NF-kappaB subunit transactivation.Semantic proximity Read ↗

The IKK complex, a central regulator of NF-kappaB activation.Semantic proximity Read ↗

A novel NF-kappaB pathway involving IKKbeta and p65/RelA Ser-536 phosphorylation results in p53 Inhibition in the absence of NF-kappaB transcriptional activity.Semantic proximity Read ↗

beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.