Article
Co- and posttranslational modification of the alpha(1B)-adrenergic receptor: effects on receptor expression and function.
Biochemistry - 2 Apr 2002
Björklöf Katja, Lundström Kenneth, Abuin Liliane, Greasley Peter J, Cotecchia Susanna
Abstract excerpt
We have characterized the maturation, co- and posttranslational modifications, and functional properties of the alpha(1B)-adrenergic receptor (AR) expressed in different mammalian cells transfected using conventional approaches or the Semliki Forest virus system. We found that the alpha(1B)-AR undergoes N-linked glycosylation as demonstrated by its sensitivity to endoglycosidases and by the effect of tunicamycin...
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