Article
N-glycosylation of the β2 adrenergic receptor regulates receptor function by modulating dimerization.
The FEBS journal - 1 Jul 2017
Li Xiaona, Zhou Mang, Huang Wei, Yang Huaiyu
Abstract excerpt
N-glycosylation is a common post-translational modification of G-protein-coupled receptors (GPCRs). However, it remains unknown how N-glycosylation affects GPCR signaling. β2 adrenergic receptor (β2 AR) has three N-glycosylation sites: Asn6, Asn15 at the N-terminus, and Asn187 at the second extracellular loop (ECL2). Here, we show that deletion of the N-glycan did not affect receptor expression and ligand...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.