Article

Substrate-directed control of N-glycosylation in the endoplasmic reticulum calibrates signal reception at the cell-surface

2024-04-27

Abstract excerpt

<h4>ABSTRACT</h4> One-fifth of human proteins are N-glycosylated in the endoplasmic reticulum (ER) by two oligosaccharyltransferases, OST-A and OST-B. Contrary to the prevailing view of N-glycosylation as a housekeeping function, we identified an ER pathway that modulates the activity of OST-A. Genetic analyses linked OST-A to HSP90B1, an ER chaperone for membrane receptors, and CCCD134, an ER protein we identify...

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Literature Corpus work: 01d8ac23-2c85-5cf9-b2b6-64c3cd97ec5c
DOI: 10.1101/2024.04.25.591210

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